Alexandru V Korotcov1,2, Caroline A Browne3, Andrew K Knutsen1,2, Dara L Dickstein2,4, Juan Wang4, Xiufen Xu2,5, Kathleen Whiting2,5, Shalini Jaiswal1,2, Allison Nathanael1, Daniel P Perl4, Zygmunt Galdzicki2,5, and Bernard J Dardzinski1,2
1Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, 3Department of Pharmacology & Molecular Therapeutics, Uniformed Services University, Bethesda, MD, United States, 4Department of Pathology, Uniformed Services University, Bethesda, MD, United States, 5Department of Anatomy, Physiology and Genetics, Neuroscience Program, Uniformed Services University, Bethesda, MD, United States
1Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, 3Department of Pharmacology & Molecular Therapeutics, Uniformed Services University, Bethesda, MD, United States, 4Department of Pathology, Uniformed Services University, Bethesda, MD, United States, 5Department of Anatomy, Physiology and Genetics, Neuroscience Program, Uniformed Services University, Bethesda, MD, United States
Behavioral tests and MRI preliminary analysis suggest that novel treatment with microglial regeneration could restore spatial memory, enhance cued fear memory and reverse some neuropathological deficits induced by chronic high-altitude exposure.
Representative T2-weighted high resolution image overlayed with manually drawn ROIs, T2 map, T1 map, FA, TR and the template MR image.
The T2, T1, FA, and TR ROIs values in four brain regions are shown on the panel. The analysis of the derived results showing elevated trace values in all selected regions in HA conditioned mice which was reversed by PLX treatment.
