Changes in Correlation Between Brain Metabolites Due to Acute Stress in Mouse Hippocampus using Proton Magnetic Resonance Spectroscopy
Chang-Soo Yun1, Yoon Ho Hwang2, Min-Hee Lee3, Wooseung Kim2, Jehyeong Yeon1, Hyeon-Man Baek4, Dong Youn Kim2, and Bong Soo Han1
1Radiation Convergence Engineering, Yonsei University, Wonju-si, Gangwon-do, Korea, Republic of, 2Biomedical Engineering, Yonsei University, Wonju-si, Gangwon-do, Korea, Republic of, 3Institute of Human Genomic Study, Korea University, Ansan-si, Gyeonggi-do, Korea, Republic of, 4Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon-si, Korea, Republic of
To
observe changes in correlations between metabolites from the glutamatergic and
aspartate systems due to acute stress using MRS.
Fig.
1. The 256 FID MRS data acquisition protocol in the acute stress experiment
using 9.4T Bruker equipment.
Fig. 2. Non-parametric sign test about correlation
coefficient value both of two experimental groups. The orange box is satisfied
with the statistically significant sign test p < 0.05. The Control group
has not significant correlation coefficient between
all metabolites. However, acute stress group have significant between Gln-GSH,
Glu-NAA, GSH-NAA.