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Multiparametric functional magnetic resonance imaging for longitudinal evaluation of liver regeneration after 70% hepatectomy in a rat model

shuangshuang xie¹, caixin qiu¹, yajie sun¹, jinxia zhu², Robert Grimm³, and wen shen¹
¹Tianjin First Central Hospital, Tianjin, China, ²MR Collaboration, Siemens Healthcare Ltd., Beijing, China, ³MR Application Development, Siemens Healthcare GmbH, Erlangen, Germany

IVIM-derived D* and DKI-derived MK can be used as non-invasive indices to monitor liver regenerative activity.

Figure 2. Longitudinal follow-up magnetic resonance imaging (MRI) measurements of liver. Intravoxel incoherent motion (IVIM)-derived parameters (D, D*, PF), diffusion kurtosis imaging (DKI)-derived parameters (MD, MK), and the blood oxygen level-dependent (BOLD)-derived parameter (R2*) of the liver parenchyma all showed regular changes from days 0 to 21 after surgery, and finally returned to baseline (bs)

Figure 1. Longitudinal changes of hepatocyte Ki - 67 indices (A) and sizes (B) from baseline (bs) to 21 days (d21) after 70% hepatectomy in rats