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Characterization of cardiac function in early-stage pulmonary arterial hypertension in asymptomatic BMPR2 mutant rats by MRI and 31P MRS
Dounia El Hamrani1,2, Julie Magat1,2, Jérôme Naulin1,2, Frédéric Perros3, Marilyne Campagnac2, David Benoist1,2, Christelle Guibert2, and Bruno Quesson1,2
1IHU LIRYC, Bordeaux, France, 2INSERM U1045, CRCTB, Bordeaux, France, 3INSERM UMR_S 999, Université Paris–Saclay, Le Kremlin Bicêtre, France
Asymptomatic transgenic rats with Bmpr2 mutation showed a decrease in end-diastolic and end-systolic volumes of ventricles leading to a reduced stroke volume. These results indicate a significant decrease in cardiac output but without hypertrophy of ventricles at this early stage.
Figure 1: Representative short-axis cine FLAH images obtained at end-systolic stage and end-diastolic stage in wild-type (WT) and transgenic (TG) rats (resolution 0.3x0.3x1mm3).
Figure 5: (A) Typical cardiac localized 31P MRS spectrum obtained in control rat; (B) Ratio phoshocreatine/ATPβ of wild type (WT, n=11) and transgenic (TG, n=12) rats for a duration of 35min prior and after dobutamine injection (10µg/kg). Mean±SEM and Groups were compared by nonparametric t test Mann-Whitney.