1244
Simultaneous morphological and quantitative lumbar MRI with 3D isotropic high-resolution using MIXTURE T2
Daichi Murayama1, Takayuki sakai1, Masami Yoneyama2, and Shigehiro Ochi1
1Radiology, Eastern Chiba Medical Center, Chiba, Japan, 2Philips Japan, Tokyo, Japan
MIXTURE could simultaneously provide morphology, pathology and T2 quantitative lumbar imaging in one single scan. It's useful to  quantitatively evaluate the tissues around lumbar for 3D T2 mapping and improve the ability of diagnostic imaging around the lumbar for 3D multi contrast MRI.

Fig.1 Scheme of the MIXTURE (Multi-Interleaved X-prepared tse with inTUitive RElaxometry).

(a) T2-mapping was performed using T2-prepared 3D segmented turbo spin- echo (TSE) with variable refocusing pulse trains. (b) Two images with different TE (TE = 0 and 50ms) were acquired with interleaved acquisition. To obtain the compatible contrasts with routine TSE images, TSE shot#1 did not apply any pre-pulses (as “PDW) and shot#2 applied both SPAIR and T2pre (as “fat-suppressed T2W”).

Fig.4 Clinical images with low back pain using MIXTURE.

(A) MIXTURE, Multiple Interleaved X-prepared TSE with Universal Relaxation-mapping Extensions,(B) Conventional 2D TSE