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Analysis of neurodegeneration using diffusion and functional MRI in FTLD model marmoset

Mitsuki Rikitake¹, Junichi Hata², Fumiko Seki³, Shinsuke Ishigaki⁴, Kuniyuki Iwata-Endo⁴, Nobuyuki Iwade⁴, Takako Shirakawa¹, Hirotaka James Okano², Hideyuki Okano⁵, and Gen Sobue⁴
¹Department of Redioligical Science, Human Health Science,　Tokyo Metroplitan University, Tokyo, Japan, ²Jikei University Graduate School of Medicine, Tokyo, Japan, ³Central Institute for Experimental Animals, Kanagawa, Japan, ⁴Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁵RIKEN Center of Brain Science, Saitama, Japan

We analyzed the degenerate in cranial nerve structure and change brain function in the marmoset FTLD model. Image analysis using structural MRI detected gray matter degeneration.Further, fMRI detected decrease in activity of the brain region, which was correlated with brain degeneration.

The results of image analysis of VBM and VBA in GM are shown.The cross-sectional image is a coronal image.In VBA analysis, from left to right, AD/FA/RD in DTI analysis, and ODI/FICVF in NODDI analysis are presented.For each image parameter, if group injected with FUS is significantly higher(p<0.05) with respect to group injected with saline (upper) before injection FUS (lower), it is represented as red, and if group injected with FUS is significantly lower(p<0.05), it is represented as blue.

The results of image analysis of VBM and VBA in WM are shown.The cross-sectional image is a coronal image.In VBA analysis, from left to right, AD/FA/RD in DTI analysis, and ODI/FICVF in NODDI analysis are presented.For each image parameter, if group injected with FUS is significantly higher(p<0.05) with respect to group injected with saline (upper) before injection FUS (lower), it is represented as red, and if group injected with FUS is significantly lower(p<0.05), it is represented as blue.