Tzu-chen Yeh1,2, Chou-ming Cheng3, and Chi-che Chou3
1Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, 2Institue of Brain Science, National Yang-Ming University, Taipei, Taiwan, 3Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan
1Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, 2Institue of Brain Science, National Yang-Ming University, Taipei, Taiwan, 3Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan
A custom-designed system was applied for inhalation of various gas mixtures and air. Independent component analysis was applied to obtain the carbogen response function for mapping of CO2-CVR. And we demonstrated the tissue, territorial and cortical specificities of CO2-CVRof human brain.
The custom designed automatic delivery system of CO2-CVR included mass flow controllers with medical graded gas mixtures and air, LabView for device control, CO2 analyzer with PoweLab and Chart 5 with synchronization with radiofrequency pulse of MRI.
Cortical specificity of CO2-CVR showed highest t values of one-sample t test using carbon response function (see text for details) as 14.53 at ventral portion of Brodmann area 23 (blue). And cortices with CO2-CVR larger than 13 were labelled as green and red for 13 < t values < 14 and t values >14, respectively.
