Pei Han1,2, Karandeep Cheema1,2, Hsu-Lei Lee1, Zhengwei Zhou1, Tianle Cao1,2, Sen Ma1, Nan Wang1, Anthony G. Christodoulou1,2, and Debiao Li1,2
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, UCLA, Los Angeles, CA, United States
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, UCLA, Los Angeles, CA, United States
We propose a fast 3D steady-state CEST method at
3T using MR Multitasking. By exploiting the correlation among images
throughout the spatial, time, and offset frequency dimensions with a low-rank
tensor, the Z-spectrum acquisition with whole-brain
coverage can be done within 5.5min.
Figure 2: Representative NOE, APT
and MT maps from Multitasking ss-CEST. Three different slices are displayed to
show the consistency of image quality within the 3D volume.
Figure 4: Average Lorentzian
amplitudes within GM and WM regions among different volunteers. The mean
amplitude is consistent among healthy subjects. Contrast ratios of WM:GM for
NOE/APT/MT: 1.21/1.10/1.22 (Multitasking ss-CEST) vs. 1.20/1.02/1.35 (2D
single-shot FLASH CEST).
