Ravi Prakash Reddy Nanga1, Mohammad Haris2, Hari Hariharan1, and Ravinder Reddy1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar
CEST contrast observed at 3ppm offset from a 10mM Glutamate and 10mM Glutamine phantom at pH 7 were 6.8% and 0.4%, respectively at B1rms of 4.2μT and 2s pulse duration. Therefore, in in vivo conditions a change in 1-2mM of glutamine would not have appreciable effect on the Glutamate contrast at 3ppm.
Figure 2: Histogram of CEST contrast at 3ppm offset at B1rms of 4.2μT and 2s pulse duration, from 10mM Glutamate and 10mM Glutamine phantom at pH 7 is shown in blue color while the one scaled to in vivo physiological concentration is shown in green color.
Figure 1: Molecular structures of Glutamate and Glutamine with the primary side chain differences, carboxylate vs amide circled in red color.
