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Static and dynamic functional connectivity in medication-free patients with obsessive compulsive disorder
Jing Liu1, Hailong Li1, Lingxiao Cao1, Xue Li2, Suming Zhang1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Sichuan University, Chengdu, China
The BNST demonstrated different connected regions in sFC and dFC in OCD, indicating their combination can provide more comprehensive information by considering both the static and time-varying aspects.
Figure 2. Brain regions with significant group difference between OCD and HC in sFC (A) and dFC (B). Warm/cool colors indicate regions showing higher/lower sFC/dFC value in the OCD group comparing with HC. The HAMA score positively correlated with dFC between the left BNST and the left lingual gyrus, and the right IOG. The illness duration positively correlated with dFC between the right BNST and right lingual gyrus (C). The warm colors indicate regions showing positive correlation with clinical scores. IOG, inferior occipital gyrus; HAMA, Hamilton Anxiety Rating Scale.
Figure 1. Flowchart illustrating analytic procedures of present study. ROI, region of interest.