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Reorganization of functional network topology in Parkinson’s disease patients with and without freezing of gait.
Karthik R Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Dietmar Cordes1, Aaron Ritter1, Jessica Caldwell1, Zoltan Mari1, and Virendra Mishra1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States
The results of our study demonstrate that despite not observing overall global or local network differences Parkinson’s disease patients with and without freezing of gait exhibit a clear shift in the topological organization when compared to the controls.
Figure 3. Rich-clubs are reorganized in the PD groups when compared to controls. (A) The Rich-club regime for NC, PD-nFOG, and PD-FOG are shown in the blue-shaded box. (B) Rich-club nodes are indicated in yellow color and non-rich-club nodes are shown in blue color for NC, PD-nFOG, and PD-FOG. Red circle – default mode network; purple circle – frontoparietal network; green circle – visual network. ‘k’ is the nodal degree. Visualized using BrainNet Viewer10
Figure 4. The difference in rich-club connectivity. Rich-club network strength, feeder network strength, and local network strength are plotted as bar plots for NC, PD-nFOG, and PD-FOG groups. Rich-club network – edges between rich-club nodes; feeder network – edges connecting non-rich-club nodes and rich club nodes; local network – edges between non-rich-club nodes. * indicates statistical significance (pcorr<0.05)