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Resting-State Functional Connectivity Predicts Cognitive Impairment Related to Type 2 Diabetes Mellitus
An ping Shi1 and Xi yang Tang2
1Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi'an, Shaanxi, China, 2Department of thoracic surgery, Tangdu Hospital, Air Force Medical University., Xi'an, China
We find that, the identified connectome-based predictive model, based on whole-brain RSFC patterns, are strong for predicting the MoCA scores in T2DM. The application of CPM to predict neurocognitive abilities can bring significant clinical benefits to patient management.
Figure 1. CPM predicts the MoCA scores from T2DM. Scatterplot of predicted MoCA scores vs actual MoCA scores. Predicted scores were generated using edges positively correlated with prediction (positive network) and negatively correlated with prediction (negative network). r, r value of Pearson's correlation between predicted MoCA scores and actual MoCA scores. Pr, P values of Pearson's correlation between predicted MoCA scores and actual MoCA scores. Pp: p values obtained from permutation tests (5000 times).