Leighton Barnden1, Sonya Marshall-Gradisnik1, Donald Staines1, and Zack Shan2
1Griffith University, Southport, QLD, Australia, 2University of Sunshine Coast, Sunshine Coast, QLD, Australia
1Griffith University, Southport, QLD, Australia, 2University of Sunshine Coast, Sunshine Coast, QLD, Australia
Rest and Task fMRI tested brainstem RAS connectivity. Fewer connections were significant in ME/CFS than HC at Rest. During Task, the same number of connections were active, but many were between different ROIs. Nerve signal conduction in the brainstem RAS
appears to be impaired in ME/CFS.
Table 1 Number of significant Connections (p-FDR < 0.05)
Figure 2 Reticular Activation System connectograms for HC and CFS during Resting State and Task. Reduced connections are seen for CFS at Rest, particularly for PoNucl.
Mdul=medulla; PoNucl=pontine nuclei; Culm=culmen;CnF=cuneiform nucleus; DoRph=dorsal Raphe; hippo=subiculum of hippocampus; iLam=thalamus intralaminar nucleus; L=left; R=right.