Courtney Whalen1, Sean Gullette2, A. Catharine Ross1, Rita Castro1,3, and Thomas Neuberger4,5
1Nutritional Sciences, The Pennsylvania State University, University Park, PA, United States, 2Huck Institute of the Life Science, The Pennsylvania State University, University Park, PA, United States, 3University of Lisbon, Lisbon, Portugal, 4Huck Institute of the Life Science, University Park, PA, United States, 5Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States
1Nutritional Sciences, The Pennsylvania State University, University Park, PA, United States, 2Huck Institute of the Life Science, The Pennsylvania State University, University Park, PA, United States, 3University of Lisbon, Lisbon, Portugal, 4Huck Institute of the Life Science, University Park, PA, United States, 5Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States
High Resolution MR microscopy allows the detailed assessment of atherosclerosis in ApoE KO mice fed. A ketogenic diet when compared with a high fat diet was protective against atherosclerosis as measured by both total plaque volume and plaque burden.
Figure 3: Representative reconstructions of aortas demonstrating differences in plaque accumulation by diet. A representative aorta from each group is presented, Control Diet (A), High Fat Diet (B), and Ketogenic Diet (C). White coloring represents the lumen of the area, dark pink denotes the atherosclerotic plaque.
Figure 2: Plaque burden varies by dietary macronutrient content in the brachiocephalic artery (A), the aortic arch (B) and total aorta (C). Data shown are the mean ± SEM, n = 4–8/group; bars not sharing not sharing letters differ by p < 0.01.