Marieke Van der Pluijm1, Laura Meershoek1, Lieuwe De Haan2, Jan Booij1, and Elsmarieke Van de Giessen1
1Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, 2Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
1Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, 2Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
The current study demonstrate the potential of
neuromelanin sensitive MRI (NM-MRI) as a potential biomarker for treatment resistance (TR) in
first episode schizophrenia patients. The predictive value of NM-MRI for TR and optimal
segmentation method still require further investigation.
Figure 2. Neuromelanin Contrast Ratio (NMcr) in treatment resistant (TR) and responders.
Figure 1. Example of the segmentation procedures on
an individual scan.
A)Individual image in MNI space B)Individual image
in MNI space with standardized mask, red represents the substantia nigra (SN).
The SN mask was drawn on a standardized average image, and then placed on the individual
data. The Crus Cerebri (CC) (not shown here) was analyzed in a similar manner.
C)Raw image D)Raw image with manually drawn masks, red represents the SN. The blue
dots represents the CC.