Huiru Li1, Huawei Zhang1, Li Yin2, Zhiyun Jia3, and Qiyong Gong1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, 3Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, 3Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China
Brain of patients with depression and suicidality showed a weaker integration (decreased
segregation and weaker integration) and altered nodal efficiency in fronto-striatal-limbic-thalamic circuit compared to healthy controls.
Group differences in global
topological properties among healthy control subjects and patients with major depressive
disorder either with or without a history of suicidality.
Regions with significant
alterations in nodal efficiency among three groups (A) and associations between clinical measures and network properties (B).