Alan Finkelstein1, Md Nasir Uddin2, Miriam Weber2, Jianhui Zhong1,3,4, and Giovanni Schifitto2,3
1Biomedical Engineering, University of Rochester, Rochester, NY, United States, 2Neurology, University of Rochester, Rochester, NY, United States, 3Imaging Sciences, University of Rochester, Rochester, NY, United States, 4Physics and Astronomy, University of Rochester, Rochester, NY, United States
1Biomedical Engineering, University of Rochester, Rochester, NY, United States, 2Neurology, University of Rochester, Rochester, NY, United States, 3Imaging Sciences, University of Rochester, Rochester, NY, United States, 4Physics and Astronomy, University of Rochester, Rochester, NY, United States
Chronic neuroinflammation in the setting of HIV infection leads to atrophy and demyelination, resulting in neurocognitive impairment. Fixel-based analysis was used to evaluate matter integrity in HIV+ individuals and their relationship with cognitive function.
Figure 2. Significant differences in fixel-based metrics between HIV-infected and HIV-uninfected individuals. (top) Fiber Density (FD), (middle) Fiber bundle Cross-section (FC), and (bottom) Fiber density and cross-section (FDC). Significant fixels (family-wise error corrected p < 0.05) were mapped to streamlines and thresholded at p < 0.05.
Figure 4. Scatterplots showing FDC as a function of Overall Z-score (A), and as a function of Executive z-score (B). Only regions with significant correlations are shown. Solid lines are linear fits and shaded areas are for 95% confidence interval. FDC: Fiber density and cross-section, IC: internal capsule.