1675
View Abstract / View Presentation
Free-Water Eliminated DTI Measures of Neuro-inflammation and White Matter Structural Deterioration in HIV-1 Clade C Infection
Teddy Salan1, Deepika Aggrawal2, Gaurav Garg2, Manju Mohanty2, Paramjeet Singh2, Mahendra Kumar1, Sameer Vyas2, and Varan Govind1
1University of Miami, Miami, FL, United States, 2Post Graduate Institute of Medical Education & Research, Chandigarh, India
We use free-water eliminated DTI (FWE-DTI) to determine the extent of micro-structural brain damage in drug-naïve HIV-1 clade C subjects. Our results show white matter structural abnormalities and inflammation manifested by increases in free water and reduced FWE fractional anisotropy.
Axial slice from an HIV-1C positive subject illustrating the different parametric maps obtained with obtained with FWE-DTI: free-water volume fraction (fFW), fractional anisotropy (FWE-FA), mean diffusivity (FWE-MD), axial diffusivity (FWE-AD), and radial diffusivity (FWE-RD). A b0 image is included for anatomical reference.
Free-water volume fraction (fFW) measured at 20 gray matter ROIs for the HIV-1C and control groups.