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Evaluation of noise/signal leaking in PCA-based DWI denoising methods
Hu Cheng1
1Indiana University, Bloomington, IN, United States
We propose a novel but simple method to evaluate noise/signal leaking in PCA-based denoising for diffusion MRI. The results show that MP-PCA has little signal leaking than LPCA but more noise leaking. 
Fig. 3. (A, E) Extracted noise from full dataset; (B, F) Extracted noise from D1; (C, G) Extracted noise from D2; (D, H) Difference image between denoised image from D1 and denoised image from D2. Top panel is the results from MP-PCA and bottom panel is the results from LPCA.
Fig. 4. Extracted noise for the extra mean volume appended to the DWI dataset by both MP-PCA and LPCA denoising.