Daria V Fomina1,2, Elnur G Sadykhov3, Petra Hanson4,5, Christopher J Philp1, Harpal S Randeva4,5, J Paul O'Hare4,5, Olga S Pavlova3,6, Nikolay V Anisimov6, Alexander M Makurenkov3, Yury A Pirogov3, Thomas M Barber4,5, Thomas Meersmann1, and Galina E Pavlovskaya1,2
1SPMIC, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, 3Faculty of Physics, Lomonosov Moscow State University, Moscow, Russian Federation, 4Warwick Medical School, University of Warwick, Coventry, United Kingdom, 5Warwickshire Institute for the Study of Diabetes Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, 6Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russian Federation
1SPMIC, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, 3Faculty of Physics, Lomonosov Moscow State University, Moscow, Russian Federation, 4Warwick Medical School, University of Warwick, Coventry, United Kingdom, 5Warwickshire Institute for the Study of Diabetes Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, 6Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russian Federation
Investigation of 23Na NMR relaxation times, T2short and T2long, in human skin samples from control and T2DM patients using 23Na MRS at 9.4T has shown a significant elongation of T2long in T2DM patients that might indicate to disease specific skin structure changes.
Figure 2. Sodium T2short and T2long obtained from bi-exponential fitting of CPMG (a) for samples collected from the foot/leg and abdomen from control patients and (b) for all samples from control and diabetic patients (samples from foot/leg and abdomen from control patients are presented together in one control group). ***P-value<0.001.
Figure 1. Sodium CPMG echo integrals of the foot/leg skin samples from control (green) and diabetic (red) patients as a function of echo time (TE). Squares represent experimental data; solid lines correspond to the calculated fitting function.
