Asaduddin Muhammad1, Wonsik Jung2, Sangyong Jon2, and Sung-Hong Park1
1Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Biological science, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of
1Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Biological science, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of
We developed three compartment model to quantify NASH progression through the use of theragnostic drugs and proper kinetic modelling. In particular, parameter k22 linearly correlates with NASH progression. This can be used to prevent further progression into liver disease such as cirrhosis.
Figure 1. Two
different models tested (Top row) accounting for different circulation
characteristic. Result of fitting (bottom row) using the two different models
Figure 3
representative k21 and k22 parameter maps from each mice group. all maps from
respective parameter shares the same colorbar range.
