Chuyao Chen1, Shaoshan Huang2, Zelong Chen1, Chenggong Yan1, Yingjie Mei3, Yikai Xu1, and Rui Guo2
1Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, China, 3Philips Healthcare, Guangzhou, China
1Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, China, 3Philips Healthcare, Guangzhou, China
A KGN/SMNP loaded cell-therapy theranostic hydrogel
scaffold for cartilage repair was developed in our study.
Figure 2 A. MR water-selective cartilage scan (3D_WATSc) for
neocartilage assessment at 3,6, 9, and 12 weeks after surgery (Left: No-treated
group, Right: Treated group). B.
Quantitative R1 relaxometry rate of the different hydrogels measured by
T1 mapping scan in vivo. C. Macroscopic
and histological observations of cartilage harvested during weeks 6 and 12
(white box: degenerated cartilage).
Figure 1 A. Schematic illustration of the experimental
protocol. B. Structural observation and MRI characterization of hydrogels. C.
T1-weigted MRI images and quantitative R1 relaxometry rate of SMNP-KGN hydrogel
at various concentrations.