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The Effect of Transmit B1 Inhomogeneity on Hyperpolarized [1-13C]-Pyruvate Metabolic MR Imaging Biomarkers

Collin J. Harlan¹, Zhan Xu¹, Christopher M. Walker¹, Keith A. Michel¹, Galen D. Reed ², and James A. Bankson^1,3
¹Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, ²GE Healthcare, Dallas, TX, United States, ³The University of Texas M.D. Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, United States

B₁⁺ maps for the ¹³C clamshell coil were measured by hand. An assessment of the impact of B₁⁺ inhomogeneities on potential biomarkers was conducted to determine acceptable regions within the ¹³C clamshell coil where deviations in B₁⁺ field homogeneity result in biomarker error within ±10%.

Figure 3. Axial, sagittal, and coronal 3D k_PLBA maps as a function of changes in pyruvate and lactate excitation angle. (a) The 3D k_PLBA map for the case when θ_P = 10°, θ_L = 10°. (b) The 3D k_PLBA map for the case when θ_P = 20°, θ_L = 20°. (c) The 3D k_PLBA map for the case when θ_P = 30°, θ_L = 30°. (d) The 3D k_PLBA map for the case when θ_P = 60°, θ_L = 60°. (e) The 3D k_PLBA map for the case when θ_P = 10°, θ_L = 30°. (f) The 3D k_PLBA map for the case when θ_P = 20°, θ_L = 30°.

Figure 1. Axial, sagittal, coronal, and multi-plane 3D view of hand measured B₁⁺ field maps at ¹³C clamshell coil isocenter. (a) The axial view of the hand measured B₁⁺ field at coil isocenter. (b) The sagittal view of the hand measured B₁⁺ field at coil isocenter. (c) The coronal view of the hand measured B₁⁺ field at coil isocenter. (d) An axial, sagittal, and coronal multi-plane 3D quadrant view of the hand measured B₁⁺ field at coil isocenter. The red contour lines in all subfigures highlight the boundaries of the volume that produces deviations in the B₁⁺ field within ±10%.