xiaoyu jiang1, sean p devan1, john c. gore1, and junzhong xu1
1Vanderbilt University Institute of Imaging Science, nashville, TN, United States
1Vanderbilt University Institute of Imaging Science, nashville, TN, United States
Using simulations, we demonstrated that an appropriate model
and analysis allow estimates of intracellular water lifetime and cell size simultaneously
over a physiologically relevant range with a $$$t_{diff}$$$ range of 5 –
100 ms, which is clinically feasible.
The hybrid model-derived intracellular
water lifetimes from the simulated diffusion data with three SNR levels ($$$\infty$$$, 50, and 25) and two different imaging protocols,
including $$$t_{diff}$$$ = 5, 30, 70, and 100 ms (blue circles) and $$$t_{diff}$$$ = 5, 30, 70,
and 200 ms (black circles).
IMPULSED- and hybrid model-derived
cell sizes from the simulated diffusion data with three SNR levels (
$$$\infty$$$, 50, and 25). The hybrid
model was applied to data with two different imaging protocols, including $$$t_{diff}$$$ = 5, 30, 70, and 100 ms (blue circles) and $$$t_{diff}$$$ = 5, 30, 70, and 200 ms (black
circles). The IMPULSED model was applied to data with $$$t_{diff}$$$ = 5, 30, 70, and
100 ms (green circles).