Tzu-Ming Hung1, Sheng-Min Huang2, Yun-Chieh Tsai3, Ting-Yu Chin4, and Hsu-Hsia Peng1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Institute of biomedical engineering and nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 3Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, 4Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, Taiwan
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Institute of biomedical engineering and nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 3Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, 4Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, Taiwan
Mice deficient in collapsin response mediator protein 1 (CRMP-1) gene possessed significantly higher rCBV in the hippocampus than wild type mice, indicating the increased blood volume in the hippocampus of CRMP-1 knockout mice.
Figure
2. The T2WI, EPI, and rCBV
maps of a wild
type (WT) and a
knockout (KO) mouse
overlaid with hippocampus ROIs (red) and whole brain ROIs (black).
Table
1. The
mean rCBV
in left, right, and total (left + right) hippocampus and the ratio of rCBV
in left to right hippocampus in wild type (WT) and knockout
(KO)
mice.