Amnah Mahroo1, Nora-Josefin Breutigam1, Jörn Huber1, and Matthias Günther1,2
1MR Physics, Fraunhofer MEVIS, Bremen, Germany, 2MR-Imaging and Spectroscopy, University of Bremen, Bremen, Germany
1MR Physics, Fraunhofer MEVIS, Bremen, Germany, 2MR-Imaging and Spectroscopy, University of Bremen, Bremen, Germany
The proposed sampling scheme provides robust exchange time estimation as a measure of blood brain barrier integrity. Furthermore, we used time efficient Hadamard ASL accelerated 3D‐GRASE imaging sequence to reduce the ASL scan times to as short as 6 min.
Figure 1:
Improved exchange time estimates. The proposed protocol provided improved
fitting of exchange time parameter for brain regions with longer ATTs such as
border zone areas.
Figure 3:
Comparison of simulated exchange time standard deviation (SD) as a measure of estimate
error. By concatenating datasets of two different sub-bolus duration, the
resulting TIs provided lower exchange time estimate errors for later ATTs.