Caterina Lapucci1,2, Marco Fiorelli3, Annunziata Stefanile4, Silvana Zannino4, Maria Maddalena Filippi5, Antonio Cortese3, Carlo Piantadosi6, Marco Salvetti7, Matilde Inglese1,8, and Tatiana Koudriavtseva4
1DINOGMI, University of Genoa, Genoa, Italy, 2Department of Experimental Neurosciences, Ospedale Policlinico San Martino IRCCS, Genoa, Italy, 3Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy, Rome, Italy, 4Department of Clinical Experimental Oncology, IRCCS Regina Elena National Cancer Institute, IFO, Rome, Italy, Rome, Italy, 5Fatebenefratelli Foundation, Afar Division, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy, Rome, Italy, 6Neurology Unit, San Giovanni-Addolorata Hospital, Rome, Italy, Rome, Italy, 7Department Of Neuroscience Mental Health And Sensory Organs (NEMOS), Sapienza University, Sant’Andrea Hospital, Rome, Italy, Rome, Italy, 8Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/, New York, NY, United States
1DINOGMI, University of Genoa, Genoa, Italy, 2Department of Experimental Neurosciences, Ospedale Policlinico San Martino IRCCS, Genoa, Italy, 3Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy, Rome, Italy, 4Department of Clinical Experimental Oncology, IRCCS Regina Elena National Cancer Institute, IFO, Rome, Italy, Rome, Italy, 5Fatebenefratelli Foundation, Afar Division, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy, Rome, Italy, 6Neurology Unit, San Giovanni-Addolorata Hospital, Rome, Italy, Rome, Italy, 7Department Of Neuroscience Mental Health And Sensory Organs (NEMOS), Sapienza University, Sant’Andrea Hospital, Rome, Italy, Rome, Italy, 8Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/, New York, NY, United States
A hyperperfusion of the Normal Appearing White Matter
(NAWM) compared to FLAIR lesions was noted. The correlations between NAWM
perfusion, disease duration and 1-year ARR in remitting patients suggested that
an increased NAWM perfusion may be a radiological marker of inflammatory
activity.
Fig.1 MRI analysis pipeline
Fig.2 Differences in perfusion parameter among NAWM, FLAIR and GD lesions
