fei gao1, fuxin ren1, weibo chen2, and muwei li3
1Shandong Medical Imaging Research Institute, Shandong University, jinan, China, 2Philips Healthcare, shanghai, China, 3Vanderbilt University Institute of Imaging Science, Nashville, TN, United States
1Shandong Medical Imaging Research Institute, Shandong University, jinan, China, 2Philips Healthcare, shanghai, China, 3Vanderbilt University Institute of Imaging Science, Nashville, TN, United States
This
study suggests that frequency-specific analysis of ALFF could provide valuable
insights into functional alterations in the auditory cortex and nonauditory
regions involved in cognitive impairment associated with PC.
Fig.1 A: The difference of ALFF between the presbycusis (PC) and normal hearing controls (NH) groups in slow-4. B: The difference of ALFF between the PC and NH groups in slow-5. Hot and cold colors indicate significantly higher and lower ALFF in the PC group than in the NH group, respectively. Results obtained by a two-sample t-test. FDR corrected p < 0.01. Abbreviations: L, left; R, right; ALFF, amplitude of low-frequency fluctuation.
Fig.4 ALFF and related FC differences between the presbycusis (PC) and normal hearing controls (NH) groups in slow-4. Between-group differences in FC analyses were only found related to the seed of left DLPFC. Hot color indicates significantly higher FC in the PC group than in the NH group, respectively. Results obtained by a two-sample t-test. FDR corrected p < 0.05. Abbreviations: L, left; R, right; ALFF, amplitude of low-frequency fluctuation; FC, functional connectivity; DLPFC, dorsolateral prefrontal cortex.