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Myelin Water Fraction Imaging in Patients with Alzheimer’s Disease and Mild Cognitive Impairment
Geon-Ho Jahng1,2, Ji Yoon Lee3, Seung-Hyun Lim1, Hak Young Rhee4, Soonchan Park1,2, Jongho Lee5, and Chang-Woo Ryu1,2
1Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 2Medicine, Kyung Hee University, Seoul, Korea, Republic of, 3Biomedical Engineering, Kyung Hee University, Yongin-si, Korea, Republic of, 4Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 5Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of
The ViSTa-GRASE sequence provides the good MWF map in a reasonable scan time to evaluate myelin loss in AD patients. MWF could serve as a potential imaging biomarker for AD for evaluating demyelination and predicting treatment outcomes.
Table 1. Summary of the statistical results of the demographic data.
Figure 1. Results of voxel-based comparisons of myelin water fraction (MWF), gray matter volume (GMV), and white matter volume (WMV) among the three participant groups.