Curtis G. Triebswetter1, Nikkita Khattar1, Matthew Kiely1, Maryam H. Alsameen1, Zhaoyuan Gong1, Susan M. Resnick2, and Mustapha Bouhrara1
1Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States, 2Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United States
1Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States, 2Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United States
· Significantly higher myelin content in adult carriers of the APOE ε2 allele as compared to noncarriers.
· Trends toward lower myelin content in adult carriers of the APOE ε4 allele as compared to noncarriers.
Figure 1. Mean myelin water fraction (MWF) values for each APOE genotype (N = 92), with
values relative to mean APOE ε33 MWF values. Results are shown for eighteen WM and GM brain
structures/ROIs. The APOE ε2/- group exhibits higher mean MWF values as compared to the
APOE ε4/- or reference groups (APOE ε33) in most ROIs while the APOE ε4/- group exhibits
lower mean MWF values as compared to the reference group in several ROIs. * indicated p <
0.05 obtained from an ANCOVA analysis.
Table 1. Slope, β, and significance, ρ, of the regression terms incorporated in the multiple linear regression given by MWF ~ β0 + βage × age + βsex × sex + βAPOE × APOE + βrace × race + βage2 × age2. Sex and race results are not shown as they exhibited overall non-significant associations with MWF in most ROIs.