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Maturation and degeneration of the human cerebrum across the adult lifespan

Matthew Kiely¹, Nikkita Khattar¹, Curtis Triebswetter¹, Zhaoyuan Gong¹, Maryam H. Alsameen¹, Richard G. Spencer¹, and Mustapha Bouhrara¹
¹Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States

· MWF and DTI indices follow quadratic associations with age

· Sex effect on MWF and DTI indices was not significant

· Weak-to-moderate regional correlations between DTI indices and MWF

Figure 1. Plots illustrating regional MWF, FA, MD, RD, or AxD values as a function of age for four representative cerebral white matter structures/ROIs. For each ROI, the coefficient of determination, R², is reported.

Figure 3. Plots illustrating examples of regional correlations of FA, MD, RD, or AxD and MWF. Results are shown for four representative cerebral white matter structures/ROIs. For each ROI, the coefficient of determination, R², is reported.