Benedictor Alexander Nguchu1, Jing Zhao 2,3, Yanming Wang1, Jean de Dieu Uwisengeyimana1, Xiaoxiao Wang1, Bensheng Qiu1, and Hongjun Li2,3
1Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China, 2Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China, 3School of Biological Science and Medical Engineering, Beihang University, Beijing, China
1Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China, 2Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China, 3School of Biological Science and Medical Engineering, Beihang University, Beijing, China
Glymphatic system activity is increased in the middle-aged HIV patients successfully adhering to cART. The increase is related to attention/working memory, suggesting a role of long-term use of cART in elevating glymphatic system and improving homeostasis for cognitive functioning.
Figure
2. Comparison of ALPS indexes
in periventricular white matter between HIV-infected individuals and healthy
controls. ALPS indexes increased significantly (p<0.05, FDR-corrected) in
middle-aged HIV-infected patients stably adhering to cART.
Figure 3. Results
of correlation analyses in middle-aged HIV patients. (A) The ALPS indexes of
the right perivascular space were correlated with attention/working memory. The
duration in which middle-aged HIV-infected patients were on antiretroviral
therapy correlated positively with the performance scores of (B) abstract and
executive function and (C) Learning and recall. Note, the correlation was
significant at p <0.05.
