2057
Clinical correlations of DTI and volumetric metrics in people with multiple sclerosis
Abdulaziz Alshehri1,2, Oun Al-iedani1,2, Jameen Arm1,2, Neda Gholizadeh1, Thibo Billiet3, Rodney Lea2, Jeannette Lechner-Scott1,2,4, and Saadallah Ramadan1,2
1University of Newcastle, Newcastle, Australia, 2Hunter Medical Research Institute, Newcastle, Australia, 3Icometrix, Leuven, Australia, 4John Hunter Hospital, Newcastle, Australia
DTI correlated with disability and mental health of RRMS patients and it is a sensitive tool in the evaluation of subtle and inconspicuous disease processes within the total brain white matter and white matter lesions that are otherwise undetectable with structural MRI.
Figure 1. Left: Population-specific FA-template for the group under study. Right: white matter mask overlaid on mean FA map.
Figure 2. Scatter plots showing some significant correlations: A) FATBWM with tARCS (r=0.412), B) RDTBWM with Memory (r=-0.467), C) ADWML with EDSS (r=0.329) and D) MDWML with DD (r=0.494).