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Microstructural Gray Matter Abnormalities in Progressive Supranuclear Palsy and Corticobasal Syndrome: Evaluation by Free-water Imaging

Koji Kamagata¹, Christina Andica¹, Kaito Takabayashi¹, Yuya Saito¹, Wataru Uchida^1,2, Shohei Fujita¹, Toshiaki Akashi¹, Akihiko Wada¹, Kouhei Kamiya³, Masaaki Hori³, and Shigeki Aoki¹
¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan, ³Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Diffusion tensor imaging and free-water imaging could detect cerebral grey matter abnormalities, which likely reflected the tau-related pathology, in corticobasal syndrome and progressive supranuclear palsy patients more sensitively than conventional voxel-based morphometry.

Figure 3. Comparison of VBM, DTI (MD, AD, and RD), and FW imaging (MDt, ADt, RDt, and FW) indices between patients with CBS and PSP and healthy controls.

The results showed reduced gray matter volume (blue–right blue voxels) and increased FW, MD, MDt, AD, ADt, RD, and RDt (red–yellow voxels) in CBS patients relative to controls (A). GBSS results showed increased FW, MD, MDt, AD, ADt, RD, and RDt (red–yellow voxels) in PSP patients relative to controls (B). GBSS results showed increased MD, MDt, AD, ADt, RD, and RDt (red–yellow voxels) in CBS patients relative to PSP patients (C).

Figure 2. Gray matter regions of interest.

Six gray matter regions, which are described in the previous literature as vulnerable to tau pathology, based on the Desikan–Killiany cortical and subcortical atlas are shown in one representative case.