2062

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Decreased sciatic nerve fractional anisotropy in diabetes and prediabetes associated with lower and upper limb function impairment

Johann ME Jende¹, Zoltan Kender¹, Christoph Mooshage¹, Sabine Heiland¹, Peter Nawroth¹, Martin Bendszus¹, Stefan Kopf¹, and Felix T Kurz¹
¹Heidelberg University Hospital, Heidelberg, Germany

A decrease in sciatic nerve fractional anisotropy in patients with diabetes and prediabetes is associated with lower and upper limb function impairment. The study findings suggest the prevalence of nerve damage at early, subclinical stages of distal polyneuropathy in diabetes.

Fig. 1. Sciatic nerve fractional anisotropy. (a) T2-weighted image of the right thigh with encircled sciatic nerve. (b) Corresponding fractional anisotropy color map. (c) Reconstructed fibre track of the right sciatic nerve.