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Reproducibility and Variability of Liver ADC Using Simultaneous Multi-slice DWI with Different Breathing Schemes and Different MR Vendors
Zheng Ye1, Bin Song1, Yuming Li1, Qing Li2, Lisha Nie3, and Xiaocheng Wei3
1West China Hospital, Sichuan University, Chengdu, China, 2MR collaborations, Siemens Healthcare Ltd., Shanghai, China, 3MR Research, GE Healthcare, Beijing, China
Regardless of breathing schemes, the measurements of liver ADC by using SMS-DWI showed good reproducibility across different MR vendors. However, the measurements were less reproducible between different breathing schemes, with breath-hold technique showing more variations.
Figure 2. Simultaneous multi-slice diffusion‑weighted images (SMS-DWI) and the corresponding apparent diffusion coefficient (ADC) maps from two breathing schemes and two vendors in a volunteer. The upper row illustrates SMS-DWI (a-d) with b value of 50 s/mm2. The lower row shows ADC maps (e-h), which were automatically generated on the MR system's console. Three circle region of interest (ROIs) in the right liver lobe were firstly draw on SMS-DWI, and pasted to corresponding ADC maps.
Figure 4. Box and whisker plots illustrates the apparent diffusion coefficient (ADC) measured in the right liver lobe from two breathing schemes and two vendors. In vendor 1 (Siemens system), the liver ADC of free-breathing SMS-DWI was significantly higher than that of breath-hold SMS-DWI (P=0.03). In vendor 2 (GE system), no significant difference was found in ADC values from different breathing schemes (P=0.42). The liver ADC values from two vendors did not show significant difference in both breathing schemes (P=0.05 and P=0.50). BH, breath-hold; FB, free-breathing.