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Diffusion kurtosis imaging (DKI) for predicting Ki-67 expression in hepatocellular carcinoma
Qiying Ke1, Tianyuan Zhang2, Xuan Jin1, Xinming Li1, Yingjie Mei3, and Xianyue Quan1
1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 2Department of Radiology, Foshan First People's Hospital, Foshan, China, 3Philips Healthcare, Guangzhou, China
Our study demonstrates that increased MK and decreased ADC values are potential predictive biomarkers for of Ki-67 expression of in HCC.
Figure 2. Images in a 36-year-old man with HCC (arrow). A, Delayed phase image showing a heterogeneous low-signal intensity lesion in segment VI of the liver. B, Diffusion map showing lower signal intensity compared with that of the liver parenchyma. The mean diffusion value of the lesion was 1.35 x 10-3 mm2/sec. C, Kurtosis map showing higher signal intensity compared with that of the liver parenchyma. The MK value of the lesion was 0.83. D, ADC map showing a lesion with a mean diffusion value of 1.18 x 10-3 mm2/sec.
Table 1. Diffusion parameters in HCC between the Ki-67>25% and Ki-67≤25% groups