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Temporal diffusion spectroscopy with oscillating gradient echoplanar MRI : signal to noise and ADC repeatability in mice liver.
Meryem Khalfallah1, Gwenaël Pagé1, Sabrina Doblas1, Bernard Van-Beers1,2, and Philippe Garteiser1
1Center of research on inflammation (UMR1149), Inserm - Université de Paris, Paris, France, 2Beaujon hospital radiology departement, APHP, Paris, France
Optimal conditions for the measurements of OGSE-EPI diffusion coefficients were assessed with a repeatability study in healthy mice. Best results were obtained using a 4-channel surface coil and respiratory gating when measuring ADC at 100 Hz
Table 1 : Repeatability study results. In bold, the optimal repeatability coefficient.
Figure 1: Examples of resulting ADC maps, superimposed on magnitude images at b-value = 0 s/mm2. A) using volume coil, B) using 4-channel parallel coil, C) without respiratory gating, D) with respiratory gating. Volume coil images have larger sensitivity area while surface coil images has higher signal magnitudes. Respiratory gating visually reduces signal artifacts.