Christian Simonsson1,2, Markus Karlsson1, Nils Dahlström1, Peter Lundberg1,2, Wolf Claus Bartholomä1,2, Gunnar Cedersund2,3, Per Sandström4, and Anna Lindhoff Larsson34
1Department of Radiation Physics, Radiology, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Medical Engineering, Linköping University, Linköping, Sweden, 43Department of Surgery, Department of biomedical and clinical sciences, Linköping University, Linköping, Sweden
1Department of Radiation Physics, Radiology, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Medical Engineering, Linköping University, Linköping, Sweden, 43Department of Surgery, Department of biomedical and clinical sciences, Linköping University, Linköping, Sweden
We have shown that there exist regional difference
in liver CA uptake, before and after resective surgery. This is a step toward
better presurgical planning for optimizing treatment outcome. Procedures are
presently less than optimal and any additional predictive ability would be beneficial.
Fig 3. The Gadoxetate
uptake model fitted to hepatic Gadoxetate concentration data (calculated from DCE-MRI images) for the four patients that underwent both pre- and post resective surgery MRI examinations. The model simulation are the green line (pre-surgery) and the orange line (post-surgery). The datapoints are green (pre-surgery) and orange (post-surgery). The column to the far right is the model fit to the mean spleen data for each of the four patients.
Fig 1. a) The mechanstic Gadoxetate
uptake model. Shown here, is a schematic over the model structure. The kin and keff model parameters represent the hepatic influx and efflux and are highlighted in orange. b) The study setup. Showing the time-points for the pre- and post resective surgery MRI examinations. c) Showing serum level blirubin for three of the patients that underwend both the pre- and post resective surgery MRI examinations.