Diana Rotaru1, Georg Oeltzschner2,3, Richard Edden2,3, and David Lythgoe1
1Neuroimaging, King's College London, London, United Kingdom, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
1Neuroimaging, King's College London, London, United Kingdom, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
A novel analysis method is proposed, the simultaneous modelling of HERMES GABA and GSH difference and sum spectra. The repeatability of this approach yielded comparable results to those produced by traditional single-spectrum analysis.
Figure.1 Transformation of the Hadamard reconstructed spectra (SUM - green, diff_GABA - red, diff_GSH - yellow) into a single concatenated spectrum with 1.2 ppm gap separation
Figure 3. Mean processed spectral data is shown for test (black) and retest (grey) acquisitions at the top; mean LCModel fits, residuals and baselines are presented for test (black) and retest (grey) at the bottom
