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Feasibility of 1H-[13C] MRS of hippocampal and hypothalamic metabolism in the very same mouse with dynamic shim update (DSU)
Hikari Yoshihara1, Nicolas Kunz2, and Hongxia Lei2,3
1EPFL-LIFMET, Lausanne, Switzerland, 2EPFL-CIBM, Lausanne, Switzerland, 3United-Imaging Co. Ltd, Wuhan, China
13C MRS of the very same mouse hippocampus and hypothalamus at 14.1T is feasible using dynamic shimming update (DSU).
Figure 1. Schematic layout of the experimental design for 1H-[13C] MRS acquisition of both hippocampus and hypothalamus with dynamic shim update (DSU) (a), and typical non-edited (b) and edited (c) MR spectra of hippocampus (blue) and hypothalamus (orange).
Figure 3. Neurochemical profiles of hippocampus and hypothalamus