Dana Goerzen1,2, Tiffany Bell3,4,5, Jamie Near1,2, and Ashley D Harris3,4,5
1McGill University, Montreal, QC, Canada, 2Centre d'Imagerie Cérébrale, Douglas Mental Health University Institute, Montreal, QC, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada, 4Hotchkiss Brain Institution, Calgary, AB, Canada, 5Alberta Children's Hospital Research Institute, Calgary, AB, Canada
1McGill University, Montreal, QC, Canada, 2Centre d'Imagerie Cérébrale, Douglas Mental Health University Institute, Montreal, QC, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada, 4Hotchkiss Brain Institution, Calgary, AB, Canada, 5Alberta Children's Hospital Research Institute, Calgary, AB, Canada
We present an analysis of MRS reliability in the human brain between 3T and 7T. We show that scyllo-inositol is reliably detected at 3T and some 7T. Further, we show that myo-inositol (mI) and phosphocholine (PCh) may be better quantified individually, rather than as mI+gly and tCho.
Figure 1. On left: Representative 2.5 x 2.5 x 2.5 cm3 voxel in occipital-parietal sulcus overlaid onto 7T MPRAGE anatomical image indicating region of MRS acquisition. Image and voxel reconstruction was performed prior to the follow-up scan, to ensure consistent placement of MRS voxel within participants. On right: fits from participant S01 for the two 7T and six 3T spectra spectra acquired in the voxel of interest.
Figure 3. Pearson’s correlation coefficient (r) computed for each metabolite between 3T sequences shown in the x-axis and 7T sequences in legend. These were then averaged across all metabolites within a 3T-7T pairing to obtain the sequence-wide average correlation between 3T measures and 7T measures of metabolites.
