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Measurement of local values of cerebral pH in mild traumatic brain injury using 1H MR spectroscopy
Peter Bulanov1, Andrei Manzhurtsev1,2, Petr Menshchikov3,4, Maxim Ublinskiy2,3, Ilya Melnikov2, Natalia Semenova1,2,3,5, and Tolib Akhadov2
1Lomonosov Moscow State University, Moscow, Russian Federation, 2Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation, 3Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation, 4PHilips Healthcare, Russia, Moscow, Russian Federation, 5Semenov Institute of Chemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation
The pH value decreases in posterior cingulate cortex after acute mTBI by ~1%. The detected change may cause biochemical disorders in brain after mTBI, associated with a change in the pH-dependent activity of enzymes.
Fig.2. Overview of the signals averaged over groups (NORM and mTBI) at 7 ppm and approximation of the signals.
Fig.1. Voxel location: posterior cingulate cortex. Size 50 x 25 x 25 mm.