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The Correlation of Neurometabolites on Presentation of Post-Concussion Phenotypes
Katherine Breedlove1, David R Howell2, Inga K Koerte3,4, Eduardo Coello4, Molly Charney4, Huijin Liao4, Corey Lanois5, and Alexander Lin4
1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Childrens Hospital Colorado, Aurora, CO, United States, 3Ludwig-Maximilians-Universitat, Munich, Germany, 4Brigham and Women's Hospital, Boston, MA, United States, 5Boston Children's Hospital, Boston, MA, United States
PCSS composite scores were found to significantly correlate with neurometabolite levels in the PCG.  Specifically, cognitive, vestibuolocular, cognitive, and sleep related scores were significantly correlated with concentrations of Glu, Glu+Gln, and NAA+NAAG.   
Fig. 5. Regression plots showing fit to PCSS composite score vs. metabolite concentration. Regression p-value and R2 are indicated.
Fig. 3. Table of significant regressions between neurometabolites and PCSS composite scores. Empty cells indicate that no significant regression was found. The p-value of the overall regression F-statistic is reported along with R2. VO=Vestibular-ocular