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Quantitative susceptibility mapping of the brain in neonates and infants

Sayo Otani¹, Yasutaka Fushimi¹, Satoshi Nakajima¹, Akihiko Sakata¹, Takuya Hinoda¹, Sonoko Oshima¹, Krishna Pandu Wicaksono¹, Hiroshi Tagawa¹, Yang Wang¹, and Yuji Nakamoto¹
¹Kyoto University Graduate School of Medicine, Kyoto, Japan

We evaluated magnetic susceptibility of a large number of pediatric subjects. Our study showed that magnetic susceptibility of the basal ganglia and thalamus increased with chronological age from birth to 2 years using volume-of-interest analysis.

Figure 1. Averaged QSM maps for neonates and infants with chronological age (CA) of 0-150 days, 151-499 days and 500-750 days. Magnetic susceptibility of the basal ganglia and thalamus increases with age.

Figure 2. Scattered plots of magnetic susceptibility of the basal ganglia and chronological age. Magnetic susceptibility of the CN, GP and PT correlates with chronological age (CA).