Raj Kumar Sharma1, Balaji Krishnamachary1, Ishwarya Sivakumar1, Yelena Mironchik1, Marie-France Penet1, Paul T Winnard Jr.1, Santosh K. Bharti1, and Zaver M. Bhujwalla1
1Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
1Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
SLC1A5 downregulation resulted in significant
reduction in tumor growth. In
tumors, SLC1A5 downregulation resulted in changes in multiple metabolites, these
results expand our understanding of the importance of SLC1A5 in tumor growth that
may lead to additional novel metabolic targets in pancreatic cancer.
Figure 3. Representative 1H MR spectra
obtained from aqueous phase extracts of Pa04C_EV and Pa04C_SLC1A5 pancreatic
cancer cells and tumors.
Figure 2. Downregulation of
SLC1A5 significantly delayed Pa04C tumor growth.