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Cerebrospinal fluid water fraction increases with age in normal aging

Thanh D Nguyen¹, Liangdong Zhou¹, Elizabeth Sweeney¹, Xiuyuan Wang¹, Susan A Gauthier¹, Yi Wang¹, Amy Kuceyeski¹, and Yi Li¹
¹Weill Cornell Medicine, New York, NY, United States

We applied FAST-T2 multi-component T2 relaxometry to 20 healthy volunteers between 30 and 60 years old and found a significant relationship between CSF water fraction and age in the frontal and temporal cortex, which may be related to the dilation of perivascular spaces in normal aging.

Figure 2. Plots of CSF water fraction (CSFF) change with age in the brain cortex and white matter of healthy volunteers (n=20). Statistical significance was found in the frontal (p=0.0011) and temporal (p=0.0093) cortex after correction for multiple comparisons.

Figure 1. Example of quantitative maps of myelin water fraction (MWF), intra/extracellular water fraction (IEWF), and CSF water fraction (CSFF) obtained by FAST-T2 sequence in a 50-year-old female subject.