2456

View Abstract / View Presentation

High-resolution microstructural imaging in the human hippocampus with b-tensor encoding and zoomed imaging

Jiyoon Yoo¹, Leevi Kerkelä¹, Patrick W. Hales¹, Kiran K. Seunarine¹, Iulius Dragonu², Enrico Kaden¹, and Christopher A. Clark¹
¹UCL Great Ormond Street Institute of Child Health, London, United Kingdom, ²Siemens Healthcare Ltd, Frimley, United Kingdom

All-in-one sequence for microstructural imaging in the hippocampus, providing high-resolution images for localisation of hippocampal subregions and fitting of standard and advanced diffusion models.

Figure 3. Derived microstructural maps and parameters. From top to bottom: Mean diffusivity (MD) from diffusion kurtosis fit, fractional anisotropy (FA) calculated from diffusion kurtosis fit, microscopic fractional anisotropy (μFA) from QTI, normalised size variance (C_MD) from QTI. STD=standard deviation.

Figure 4. (A) Mean diffusion-weighted LTE image at b-value of 1000 s/mm² shows contrast within the hippocampal subregions. Subregions were manually segmented for subiculum (blue), Cornu Ammonis (CA) regions CA1-3 (red) and CA4 with dentate gyrus (DG, yellow). (B) Microstructural parameters were calculated in each subregion; Subiculum, CA1-3 and CA4/DG.