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Adequate mixing time for double diffusion encoding in normal brain structures and brain tumors
Kentaro Akazawa1, Koji Sakai1, Tomoaki Kitaguchi1, Tomonori Toyotsuji1, Thorsten Feiweier 2, Hiroshi Imai3, and Kei Yamada1
1Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Siemens Healthcare K.K., Shinagawa, Japan
A relatively short mixing time of 30 msec for double diffusion encoding is likely adequate to evaluate the microscopic fractional anisotropy not only in the normal brain structures, but also in pathologically abnormal areas such as brain tumors.
The scatter plots of relative signal intensities in the enhanced lesions in brain tumors, the normal thalamus, the normal white matters, and the lateral ventricle. The horizontal and vertical axes are relative signal intensities from the parallel directions and from the anti-parallel directions, respectively. There were significantly correlated in all areas (p < 0.001).
The scatter plots of relative signal intensities in the enhanced lesions, the normal thalamus, the normal white matters, and the lateral ventricle. The horizontal and vertical axes are relative signal intensities from the collinear directions which are the averages of the parallel and anti-parallel directions, and from the orthogonal directions, respectively. There were significantly correlated in all areas (p < 0.001). The slopes of the thalamus and white matter seemed to be different from those in figure 2.