Quan Tao1, Peiwei Yi1, Zimeng Cai1, Yingjie Mei2, Ruiyuan Liu1, and Yanqiu Feng1
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips healthcare, Guangzhou, China
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips healthcare, Guangzhou, China
The combination of
iobitridol and iodixanol with the mixed ratio of 1:1 was found to be the best
for pH mapping. Improved accuracy and extended pH detection range have been
achieved under a single reduced B1 of 1.5 μΤ, which enable the
reliable pH mapping of kidney in vivo.
Figure
4. In vivo Z-spectra of cortex (a), medulla (b) and calyx (c) in one rat kidney
after intravenous injection of iodixanol and iobitridol mixture, and the
fitting results using the multi-pools Lorentzian model .
Figure 5. Resolved
maps of two CEST effects at 4.3 ppm (a) and 5.5 ppm (b) obtained from acquired
Z-spectra of one rat kidney under a saturation power of 1.5 μT; Ratiometric
image (c) and the pH map (d) obtained from the two CEST effects.